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INVESTIGATOR PROFILES

Stewart Sell

RESEARCH PHYSICIAN Wadsworth Center,
Diagnostic Oncology

SENIOR SCIENTIST
Ordway Research Institute

PROFESSOR
University at Albany,
School of Public Health,
Biomedical Sciences

B.S. College of William and Mary in Virginia, 1956

M.D. University of Pittsburgh, 1960

Residency in Pathology, Massachusetts General Hospital

Post-doctoral Fellowship, U. Birmingham, England

CONTACT
Adult Stem Cells &
Cancer Laboratory
Phone: (518) 474-0547
Fax: (518) 473-2900
ssell@ordwayresearch.org

Stewart Sell, M.D.

Ongoing Research

  • Cancer: To determine how bone marrow derived mesenchymal stem cells influence the development of cancers in other tissues.
  • Cancer: To block proliferation of breast cancer stem cells by small molecular inhibitors or inhibitory RNA. This is a critical step to preventing re-growth of breast cancer after chemotherapy or radiation therapy.
  • Carcinogenesis: To study the metabolism of aflatoxin and development of liver cancer in mice lacking glutathionine-S-transferase.
  • Aging: To compare the ability of young vs. old bone marrow derived stem cells to reconstitute and provide long term survival after lethal irradiation and transplantation, and the ability of wild-type bone marrow to prolong life of early aging mice.

Honors and Awards

  • Listed in Current Contents as one of 1,000 most quoted scientists, 1981
  • Paper listed as "Citation Classic" by Current Contents, 1984                 
  • Philip S. Hench Distinguished Alumnus Award, U. Pittsburgh School of Medicine, 1988
  • Distinguished Scientist Award, International Academy of Tumor Marker Oncology, 1998
  • Gary J. Miller Memorial Award for excellence in teaching, AACR, 2002
  • Rudolph L. K. Virchow Award, LeadershipMedica, ITALY, 2005
  • Legacy Laureate, University of Pittsburgh (Highest Honor for Alumni), 2005.
  • Paper cited as Scientific Landmark in Cancer Research by the American Association for Cancer Research, 2007
  • Abbott Award of the International Society for Oncodevelopmental Biology and Medicine, 2007
  • Keynote Speaker, International Academy of Pathology, Athens, Greece, 2008

Selected Publications (View)

  • Ilic Z, Crawford D, Vakaria, D, Egner PA, Sell S. Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1. Toxicol. & Applied Pharmacol. 242:241–246, 2010.
  • McKinstry KK, Strutt TM, Buck A, Curtis J, Dibble JP, Huston Gail, Tighe M, Hamada H, Sell S, Dutton RW, Swain SL. IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge. J. Immunol. 182: 7353–7363, 2009.
  • Glinskii AB, Ma J, Ma S, Grant D, Lim CU, Sell S, Glinsky GV.
    Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders. Cell Cycle 23:3925-3942, 2009.
  • Guest I, Ilic Z, Ma J, Glinsky G, Sell S. Direct and indirect contribution of bone marrow derived cells to cancer. Int. J. Cancer. Published Online: 8 Oct 2009. PMID: 19816927
  • Sell, S. Alpha-fetoprotein, Stem Cells, and Cancer. The Abbot Award Lecture. Tumor Biology, 29:161-180, 2008.
  • Sell S, Leffert HL. Liver Cancer Stem Cells. J. Clin. Oncology.26:2800-2805, 2008. 
  • Sell S. Cancer and Stem Cell Signaling: A Guide to Preventive and Therapeutic Strategies for Cancer Stem Cells. Stem Cell Reviews, 3:1-6, 2007.
  • Sell S. Stem cells in hepatocarcinogenesis. Cell Science Reviews, ISN NO. 1742-8130, 2006.
  • Sell S. Potential gene therapy for cancer stem cells. Current Gene Therapy. 6:579-591, 2006
  • Crawford, DR, Ostrowski S, Vakharia D, Ilic, Z, Sell S. Separate evolution of hepatitis B virus negative foci and hepatocellular carcinomas in transgenic HBsAg (alb/psx) mice. Am. J. Pathology, 169:223-232, 2006
  • Sell S. Stem cell origin of cancer and differentiation therapy. Crit. Rev. Oncology and Hematology, 52:1-28, 2004.
  • Sell, S. and Pierce, G. B. Biology of Disease: Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers.  Lab. Invest. 70:6-21, 1994.    An AACR Scientific Landmark  
  • Sell, S. and Gell, P.G.H. Studies on rabbit lymphocytes in vitro. I. Stimulation of blast transformation with an antiallotype serum.  J. Exp. Med. 122:423‑441, 1965. A Current Contents Citation Classic